A New Admissible Heuristic for Minimal-Cost Proofs
Abstract
The use of immune checkpoint inhibitors (ICIs) can improve survival of patients with malignant tumors, however, the ICI treatment is associated with unpredictable toxicity as immune-related adverse effects (irAEs). Here we report two cases of metastatic malignant gastrointestinal tumors where severe immune-mediated hepatotoxicity (IMH) developed, characterized by liver failure, after the ICI therapy. Through a strong immunosuppressive treatment and a non-biological artificial liver and supportive treatment, the liver function was restored in both cases, and the anti-tumor treatment effect was guaranteed. These results showed that the non-biological artificial liver could be capable of improve prognosis during the ICI therapy.
Cite
Text
Charniak and Husain. "A New Admissible Heuristic for Minimal-Cost Proofs." AAAI Conference on Artificial Intelligence, 1991. doi:10.3389/fimmu.2022.1001823Markdown
[Charniak and Husain. "A New Admissible Heuristic for Minimal-Cost Proofs." AAAI Conference on Artificial Intelligence, 1991.](https://mlanthology.org/aaai/1991/charniak1991aaai-new/) doi:10.3389/fimmu.2022.1001823BibTeX
@inproceedings{charniak1991aaai-new,
title = {{A New Admissible Heuristic for Minimal-Cost Proofs}},
author = {Charniak, Eugene and Husain, Saadia},
booktitle = {AAAI Conference on Artificial Intelligence},
year = {1991},
pages = {446-451},
doi = {10.3389/fimmu.2022.1001823},
url = {https://mlanthology.org/aaai/1991/charniak1991aaai-new/}
}