Deep Convolutional Neural Networks for Human Embryonic Cell Counting

Abstract

We address the problem of counting cells in time-lapse microscopy images of developing human embryos. Cell counting is considered as an important step in analyzing biological phenomenon such as embryo viability. Traditional approaches to counting cells rely on hand crafted features and cannot fully take advantage of the growth in data set sizes. In this paper, we propose a framework to automatically count the number of cells in developing human embryos. The framework employs a deep convolutional neural network model trained to count cells from raw microscopy images. We demonstrate the effectiveness of our approach on a data set of 265 human embryos. The results show that the proposed framework provides robust estimates of the number of cells in a developing embryo up to the 5-cell stage (i.e., 48 h post fertilization).