ML Anthology

Classifying Stem Cell Differentiation Images by Information Distance

Xianglilan Zhang, Hongnan Wang, Tony J. Collins, Zhigang Luo, Ming Li
ECML-PKDD 2012 pp. 269-282
doi:10.1007/978-3-642-33460-3_23 /ecmlpkdd/2012/zhang2012ecmlpkdd-classifying/

Abstract

The ability of stem cells holds great potential for drug discovery and cell replacement therapy. To realize this potential, effective high content screening for drug candidates is required. Analysis of images from high content screening typically requires DNA staining to identify cell nuclei to do cell segmentation before feature extraction and classification. However, DNA staining has negative effects on cell growth, and segmentation algorithms err when compound treatments cause nuclear or cell swelling/shrinkage. In this paper, we introduced a novel Information Distance Classification (IDC) method, requiring no segmentation or feature extraction; hence no DNA staining is needed. In classifying 480 candidate compounds that may be used to stimulate stem cell differentiation, the proposed IDC method was demonstrated to achieve a 3% higher F_1 score than conventional analysis. As far as we know, this is the first work to apply information distance in high content screening.

PDF ECML-PKDD Semantic Scholar

Cite

Text

Zhang et al. "Classifying Stem Cell Differentiation Images by Information Distance." European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases, 2012. doi:10.1007/978-3-642-33460-3_23

Markdown

[Zhang et al. "Classifying Stem Cell Differentiation Images by Information Distance." European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases, 2012.](https://mlanthology.org/ecmlpkdd/2012/zhang2012ecmlpkdd-classifying/) doi:10.1007/978-3-642-33460-3_23

BibTeX

@inproceedings{zhang2012ecmlpkdd-classifying,
  title     = {{Classifying Stem Cell Differentiation Images by Information Distance}},
  author    = {Zhang, Xianglilan and Wang, Hongnan and Collins, Tony J. and Luo, Zhigang and Li, Ming},
  booktitle = {European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases},
  year      = {2012},
  pages     = {269-282},
  doi       = {10.1007/978-3-642-33460-3_23},
  url       = {https://mlanthology.org/ecmlpkdd/2012/zhang2012ecmlpkdd-classifying/}
}