ZAPBench: A Benchmark for Whole-Brain Activity Prediction in Zebrafish
Abstract
Data-driven benchmarks have led to significant progress in key scientific modeling domains including weather and structural biology. Here, we introduce the Zebrafish Activity Prediction Benchmark (ZAPBench) to measure progress on the problem of predicting cellular-resolution neural activity throughout an entire vertebrate brain. The benchmark is based on a novel dataset containing 4d light-sheet microscopy recordings of over 70,000 neurons in a larval zebrafish brain, along with motion stabilized and voxel-level cell segmentations of these data that facilitate development of a variety of forecasting methods. Initial results from a selection of time series and volumetric video modeling approaches achieve better performance than naive baseline methods, but also show room for further improvement. The specific brain used in the activity recording is also undergoing synaptic-level anatomical mapping, which will enable future integration of detailed structural information into forecasting methods.
Cite
Text
Lueckmann et al. "ZAPBench: A Benchmark for Whole-Brain Activity Prediction in Zebrafish." International Conference on Learning Representations, 2025.Markdown
[Lueckmann et al. "ZAPBench: A Benchmark for Whole-Brain Activity Prediction in Zebrafish." International Conference on Learning Representations, 2025.](https://mlanthology.org/iclr/2025/lueckmann2025iclr-zapbench/)BibTeX
@inproceedings{lueckmann2025iclr-zapbench,
title = {{ZAPBench: A Benchmark for Whole-Brain Activity Prediction in Zebrafish}},
author = {Lueckmann, Jan-Matthis and Immer, Alexander and Chen, Alex Bo-Yuan and Li, Peter H. and Petkova, Mariela D and Iyer, Nirmala A and Hesselink, Luuk Willem and Dev, Aparna and Ihrke, Gudrun and Park, Woohyun and Petruncio, Alyson and Weigel, Aubrey and Korff, Wyatt and Engert, Florian and Lichtman, Jeff and Ahrens, Misha and Januszewski, Michal and Jain, Viren},
booktitle = {International Conference on Learning Representations},
year = {2025},
url = {https://mlanthology.org/iclr/2025/lueckmann2025iclr-zapbench/}
}