Computational Design of Novel Ampar and Nmdar Peptide Modulators.
Abstract
AMPA and NMDA ionotropic glutamate receptors are the most prominent therapeutic targets in the broad spectrum of neurological diseases. Here we design novel peptide binders to these receptors, which are able to modulate these receptors’ physiological activity. We demonstrate that designed peptides have high affinity to selected targets in comparison to small molecules agonists by using molecular dynamics methods as well as modulator activity on rat cortical neuronal cell cultures by fluorescent calcium microscopy.
Cite
Text
Rustamov et al. "Computational Design of Novel Ampar and Nmdar Peptide Modulators.." ICLR 2024 Workshops: GEM, 2024.Markdown
[Rustamov et al. "Computational Design of Novel Ampar and Nmdar Peptide Modulators.." ICLR 2024 Workshops: GEM, 2024.](https://mlanthology.org/iclrw/2024/rustamov2024iclrw-computational/)BibTeX
@inproceedings{rustamov2024iclrw-computational,
title = {{Computational Design of Novel Ampar and Nmdar Peptide Modulators.}},
author = {Rustamov, Khondamir and Nebesnaya, Kamila and Baev, Artyom Y.},
booktitle = {ICLR 2024 Workshops: GEM},
year = {2024},
url = {https://mlanthology.org/iclrw/2024/rustamov2024iclrw-computational/}
}