A Universal Generalization for Temporal-Difference Learning Using Haar Basis Functions
Abstract
The effect of intracellular perfusion with cyclic GMP (cGMP) on Ca current (Ica) was investigated in Cs-loaded isolated cells from guinea pig ventricle using the whole-cell patch-clamp technique and a perfused patch pipette. cGMP (5 microM) strongly reduced Ica which had been elevated by intracellular perfusion with 50 microM of either cyclic AMP (cAMP) or its hydrolysis-resistant analog 8-Bromo-cAMP. In addition, cGMP prevented the stimulation of Ica by IBMX, a phosphodiesterase inhibitor. The membrane permeant cGMP analog 8-Bromo-cGMP (100 microM), when applied outside the cell, also antagonized the stimulatory effect of IBMX on Ica. It is concluded that cGMP inhibits Ica in guinea pig ventricular cells by a mechanism different from the activation of a cGMP-stimulated phosphodiesterase recently found in frog ventricular cells.
Cite
Text
Katayama et al. "A Universal Generalization for Temporal-Difference Learning Using Haar Basis Functions." International Conference on Machine Learning, 2000.Markdown
[Katayama et al. "A Universal Generalization for Temporal-Difference Learning Using Haar Basis Functions." International Conference on Machine Learning, 2000.](https://mlanthology.org/icml/2000/katayama2000icml-universal/)BibTeX
@inproceedings{katayama2000icml-universal,
title = {{A Universal Generalization for Temporal-Difference Learning Using Haar Basis Functions}},
author = {Katayama, Susumu and Kimura, Hajime and Kobayashi, Shigenobu},
booktitle = {International Conference on Machine Learning},
year = {2000},
pages = {447-454},
url = {https://mlanthology.org/icml/2000/katayama2000icml-universal/}
}