Flow-Field Inference from Neural Data Using Deep Recurrent Networks

Abstract

Neural computations underlying processes such as decision-making, working memory, and motor control are thought to emerge from neural population dynamics. But estimating these dynamics remains a significant challenge. Here we introduce Flow-field Inference from Neural Data using deep Recurrent networks (FINDR), an unsupervised deep learning method for inferring low-dimensional, nonlinear, stochastic dynamics underlying neural population activity. Using spike train data from frontal brain regions of rats performing an auditory decision-making task, we demonstrate that FINDR performs competitively with existing methods in capturing the heterogeneous responses of individual neurons. When trained to disentangle task-relevant and irrelevant activity, FINDR uncovers interpretable low-dimensional dynamics. These dynamics can be visualized as flow fields and attractors, enabling direct tests of attractor-based theories of neural computation. We suggest FINDR as a powerful method for revealing the low-dimensional task-relevant dynamics of neural populations and their associated computations.