AbFlex: Predicting the Conformational Flexibility of Antibody CDRs
Abstract
Proteins are highly flexible macromolecules and the ability to adapt their shape is fundamental to many functional properties. While a single, 'static' protein structure can be predicted at high accuracy, current methods are severely limited at predicting structural flexibility. A major factor limiting such predictions is the scarcity of suitable training data. Here, we focus on the functionally important antibody CDRs and related loop motifs. We implement a strategy to create a large dataset of evidence for conformational flexibility and develop AbFlex, a method able to predict CDR flexibility with high accuracy.
Cite
Text
Spoendlin et al. "AbFlex: Predicting the Conformational Flexibility of Antibody CDRs." ICML 2024 Workshops: ML4LMS, 2024.Markdown
[Spoendlin et al. "AbFlex: Predicting the Conformational Flexibility of Antibody CDRs." ICML 2024 Workshops: ML4LMS, 2024.](https://mlanthology.org/icmlw/2024/spoendlin2024icmlw-abflex/)BibTeX
@inproceedings{spoendlin2024icmlw-abflex,
title = {{AbFlex: Predicting the Conformational Flexibility of Antibody CDRs}},
author = {Spoendlin, Fabian C and Wong, Wing Ki and Georges, Guy and Bujotzek, Alexander and Deane, Charlotte},
booktitle = {ICML 2024 Workshops: ML4LMS},
year = {2024},
url = {https://mlanthology.org/icmlw/2024/spoendlin2024icmlw-abflex/}
}