Overview of a Display-Oriented Editor for INTERLISP
Abstract
Drugs for the treatment and prevention of nervous system diseases must permeate the blood-brain barrier to take effect. In vitro models of the blood-brain barrier are therefore important in the investigation of drug permeation mechanisms. However, to date, no unified method has been described for establishing a blood-brain barrier model. Here, we modified an in vitro model of the blood-brain barrier by seeding brain microvascular endothelial cells and astrocytes from newborn rats on a polyester Transwell cell culture membrane with 0.4-µm pores, and conducted transepithelial electrical resistance measurements, leakage tests and assays for specific blood-brain barrier enzymes. We show that the permeability of our model is as low as that of the blood-brain barrier in vivo. Our model will be a valuable tool in the study of the mechanisms of action of neuroprotective drugs.
Cite
Text
Barstow. "Overview of a Display-Oriented Editor for INTERLISP." International Joint Conference on Artificial Intelligence, 1981. doi:10.4103/1673-5374.172320Markdown
[Barstow. "Overview of a Display-Oriented Editor for INTERLISP." International Joint Conference on Artificial Intelligence, 1981.](https://mlanthology.org/ijcai/1981/barstow1981ijcai-overview/) doi:10.4103/1673-5374.172320BibTeX
@inproceedings{barstow1981ijcai-overview,
title = {{Overview of a Display-Oriented Editor for INTERLISP}},
author = {Barstow, David R.},
booktitle = {International Joint Conference on Artificial Intelligence},
year = {1981},
pages = {927-929},
doi = {10.4103/1673-5374.172320},
url = {https://mlanthology.org/ijcai/1981/barstow1981ijcai-overview/}
}