ML Anthology

Simulations of a Reconstructed Cerebellar Purkinje Cell Based on Simplified Channel Kinetics

Paul C. Bush, Terrence J. Sejnowski
NeCo 1991 pp. 321-332
doi:10.1162/NECO.1991.3.3.321 /neco/1991/bush1991neco-simulations/

Abstract

When cerebellar Purkinje cells are depolarized with a constant current pulse injected at the soma, complex spike discharge patterns are observed (Llinas and Sugimori 1980b). A computer model has been constructed to analyze how the Purkinje cell ionic conductance identified to date interact to produce the observed firing behavior. The kinetics of voltage-dependent conductance used in the model were significantly simpler than Hodgkin-Huxley kinetics, which have many parameters that must be experimentally determined. Our simplified scheme was able to reproduce the complex nonlinear responses found in real Purkinje cells. A similar approach could be used to study the wide variety of neurons found in different brain regions.

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Cite

Text

Bush and Sejnowski. "Simulations of a Reconstructed Cerebellar Purkinje Cell Based on Simplified Channel Kinetics." Neural Computation, 1991. doi:10.1162/NECO.1991.3.3.321

Markdown

[Bush and Sejnowski. "Simulations of a Reconstructed Cerebellar Purkinje Cell Based on Simplified Channel Kinetics." Neural Computation, 1991.](https://mlanthology.org/neco/1991/bush1991neco-simulations/) doi:10.1162/NECO.1991.3.3.321

BibTeX

@article{bush1991neco-simulations,
  title     = {{Simulations of a Reconstructed Cerebellar Purkinje Cell Based on Simplified Channel Kinetics}},
  author    = {Bush, Paul C. and Sejnowski, Terrence J.},
  journal   = {Neural Computation},
  year      = {1991},
  pages     = {321-332},
  doi       = {10.1162/NECO.1991.3.3.321},
  volume    = {3},
  url       = {https://mlanthology.org/neco/1991/bush1991neco-simulations/}
}