Minimal Model for Intracellular Calcium Oscillations and Electrical Bursting in Melanotrope Cells of Xenopus Laevis
Abstract
A minimal model is presented to explain changes in frequency, shape, and amplitude of Ca2+ oscillations in the neuroendocrine melanotrope cell of Xenopus Laevis. It describes the cell as a plasma membrane oscillator with influx of extracellular Ca2+ via voltage-gated Ca2+ channels in the plasma membrane. The Ca2+ oscillations in the Xenopus melanotrope show specific features that cannot be explained by previous models for electrically bursting cells using one set of parameters. The model assumes a KCa-channel with slow Ca2+ -dependent gating kinetics that initiates and terminates the bursts. The slow kinetics of this channel cause an activation of the KCa-channel with a phase shift relative to the intracellular Ca2+ concentration. The phase shift, together with the presence of a Na+ channel that has a lower threshold than the Ca2+ channel, generate the characteristic features of the Ca2+ oscillations in the Xenopus melanotrope cell.
Cite
Text
Cornelisse et al. "Minimal Model for Intracellular Calcium Oscillations and Electrical Bursting in Melanotrope Cells of Xenopus Laevis." Neural Computation, 2001. doi:10.1162/089976601300014655Markdown
[Cornelisse et al. "Minimal Model for Intracellular Calcium Oscillations and Electrical Bursting in Melanotrope Cells of Xenopus Laevis." Neural Computation, 2001.](https://mlanthology.org/neco/2001/cornelisse2001neco-minimal/) doi:10.1162/089976601300014655BibTeX
@article{cornelisse2001neco-minimal,
title = {{Minimal Model for Intracellular Calcium Oscillations and Electrical Bursting in Melanotrope Cells of Xenopus Laevis}},
author = {Cornelisse, L. Niels and Scheenen, Wim J. J. M. and Koopman, Werner J. H. and Roubos, Eric W. and Gielen, Stan C. A. M.},
journal = {Neural Computation},
year = {2001},
pages = {113-137},
doi = {10.1162/089976601300014655},
volume = {13},
url = {https://mlanthology.org/neco/2001/cornelisse2001neco-minimal/}
}