Amplifying and Linearizing Apical Synaptic Inputs to Cortical Pyramidal Cells
Abstract
Intradendritic electrophysiological recordings reveal a bewildering repertoire of complex electrical spikes and plateaus that are dif(cid:173) ficult to reconcile with conventional notions of neuronal function. In this paper we argue that such dendritic events are just an exu(cid:173) berant expression of a more important mechanism - a proportional current amplifier whose primary task is to offset electrotonic losses. Using the example of functionally important synaptic inputs to the superficial layers of an anatomically and electrophysiologically re(cid:173) constructed layer 5 pyramidal neuron, we derive and simulate the properties of conductances that linearize and amplify distal synap(cid:173) tic input current in a graded manner. The amplification depends on a potassium conductance in the apical tuft and calcium conduc(cid:173) tances in the apical trunk.
Cite
Text
Bernander et al. "Amplifying and Linearizing Apical Synaptic Inputs to Cortical Pyramidal Cells." Neural Information Processing Systems, 1993.Markdown
[Bernander et al. "Amplifying and Linearizing Apical Synaptic Inputs to Cortical Pyramidal Cells." Neural Information Processing Systems, 1993.](https://mlanthology.org/neurips/1993/bernander1993neurips-amplifying/)BibTeX
@inproceedings{bernander1993neurips-amplifying,
title = {{Amplifying and Linearizing Apical Synaptic Inputs to Cortical Pyramidal Cells}},
author = {Bernander, Öjvind and Koch, Christof and Douglas, Rodney J.},
booktitle = {Neural Information Processing Systems},
year = {1993},
pages = {519-526},
url = {https://mlanthology.org/neurips/1993/bernander1993neurips-amplifying/}
}