Patterns of Damage in Neural Networks: The Effects of Lesion Area, Shape and Number
Abstract
Current understanding of the effects of damage on neural networks is rudimentary, even though such understanding could lead to im(cid:173) portant insights concerning neurological and psychiatric disorders. Motivated by this consideration, we present a simple analytical framework for estimating the functional damage resulting from fo(cid:173) cal structural lesions to a neural network. The effects of focal le(cid:173) sions of varying area, shape and number on the retrieval capacities of a spatially-organized associative memory. Although our analyti(cid:173) cal results are based on some approximations, they correspond well with simulation results. This study sheds light on some important features characterizing the clinical manifestations of multi-infarct dementia, including the strong association between the number of infarcts and the prevalence of dementia after stroke, and the 'mul(cid:173) tiplicative' interaction that has been postulated to occur between Alzheimer's disease and multi-infarct dementia.
Cite
Text
Ruppin and Reggia. "Patterns of Damage in Neural Networks: The Effects of Lesion Area, Shape and Number." Neural Information Processing Systems, 1994.Markdown
[Ruppin and Reggia. "Patterns of Damage in Neural Networks: The Effects of Lesion Area, Shape and Number." Neural Information Processing Systems, 1994.](https://mlanthology.org/neurips/1994/ruppin1994neurips-patterns/)BibTeX
@inproceedings{ruppin1994neurips-patterns,
title = {{Patterns of Damage in Neural Networks: The Effects of Lesion Area, Shape and Number}},
author = {Ruppin, Eytan and Reggia, James A.},
booktitle = {Neural Information Processing Systems},
year = {1994},
pages = {35-42},
url = {https://mlanthology.org/neurips/1994/ruppin1994neurips-patterns/}
}